OTC and lung cancer: For UL197, SeM at 500 μM (❚) had in general much attenuated or even stimulatory effects (e.g., m2-citrate, m2-lactate) on the 13C6-Glc metabolism in CA OTC (Figure S10), which is consistent with the effects of SeM on glucose metabolism in lung cancer cells (Figure 2 and Figure S7A).