Chen et al. reported that while patients with BC and overweight or obesity might have a high frequency of HER2+ subtypes, their risk is still not significantly elevated: odds ratio (OR) = 1.24 (95% confidence interval (CI) = 0.81–1.88) and OR = 1.41 (95% CI = 0.92–2.16) for women with overweight and obesity, respectively [47]. The gene discussed is ERBB2; the disease is obesity due to melanocortin 4 receptor deficiency.