BECact/dys is induced by: (1) proinflammatory cytokines, such as tumor necrosis alpha and interleukin-6; (2) turbulent blood flow, such as occurs at bifurcations and branch points of arteries; (3) advanced glycation end-products, which are elevated in hyperglycemia and aging; and (4) inflammatory stressors such as metainflammation pCC, from VAT depots and plasma membrane peptides of gram-negative bacteria such as soluble LPS and LPS extracellular exosomes from gut microbiota dysbiotic regions. The gene discussed is IL6; the disease is Hyperglycemia.