Conversely, patients with a poor response to locoregional therapies upon final pathology were at high risk of post-transplant recurrence [29] Response to treatment can be evaluated through imaging and tumor markers (e.g., AFP or gamma glutamyl transpeptidase) [30] Other studies have also demonstrated that a reduction in AFP to <500 ng/mL was associated with a decreased risk of HCC recurrence and improved post-transplant mortality [31]. This evidence concerns the gene AFP and hepatocellular carcinoma.