CD40LG and infection: COVID-19 patients generally show a rapid increase in SARS-CoV-2-specific IgM, and IgG, commonly observed around a week after the infection [11], however, comorbidities may also have an impact not only on the inflammatory response during COVID-19 but also on antibody production, as seen in earlier reports in human immunodeficiency virus (HIV) patients presenting a delayed SARS-CoV-2 specific IgM and IgG production [33].