A total of 12 genes (BAG3, DES, DSP, FLNC, LMNA, MYH7, PLN, RBM20, SCN5A, TNNC1, TNNT2, and TTN) with strong and definitive classifications have a role in DCM that has been clearly demonstrated in the literature [PMID: 33947203]. The gene discussed is DES; the disease is familial dilated cardiomyopathy.