However, contrary results have been suggested by certain reports for the correlation between LGR5 staining scores and the prognosis of CRC [5], for example, a genetic study published in 2012 by Ziskin et al. [55] and an immunohistochemical study published in 2019 by Shekarriz et al. [56] reported that LGR5 expression was not seen significantly associated with the aggressiveness of colorectal tumors. Here, LGR5 is linked to colorectal neoplasm.