However, the American Diabetes Association recommendations on alcohol intake should be followed: one drink a day for women and up to two per day for men (5 ounces of wine, a 12-ounce beer, or one and a half ounces of 80-proof spirits), because there are potential risks associated with alcohol consumption by T2DM patients, such as an increased hypoglycaemic risk, particularly when insulin and sulphonylureas are prescribed [43]. Here, INS is linked to type 2 diabetes mellitus.