INS and type 2 diabetes mellitus: As shown by the Restoring Insulin Secretion (RISE) Study, which randomized youth with impaired glucose tolerance or recently diagnosed T2D 1:1 to either metformin alone for 12 months or 3 months of insulin glargine followed by 9 months of metformin, the rate of glycemic worsening did not differ between groups and occurred in 17.8% and 36% of youth overall at 12 and 21 months, respectively [35].