The results of an animal study on female BALB/c mice that received glycyrrhizin (0.5 mg/day for two months) demonstrated that glycyrrhizin’s inhibition of HMGB1 function caused a sharp decline in serum HMGB1 levels, which in turn decreased the severity of SLE [110]. This evidence concerns the gene HMGB1 and systemic lupus erythematosus.