The angiogenic factors Vascular Endothelial Growth Factor (VEGF), IL-8, basic fibroblast growth factor (bFGF), and platelet-derived endothelial growth factor (PDGF) have been detected in OSCC and were correlated with tumor microvessel density (TMD), a representative marker of angiogenesis [37]. This evidence concerns the gene VEGFA and neoplasm.