Prognostic Value Regarding HyperTension And Target Organ Damage), has reported that patients with severe obesity scheduled to undergo bariatric surgery [80] showed a statistically significant decrease in plasmatic renin activity (PRA), aldosterone, angiotensin-converting enzyme (ACE) activity with an increase in the ACE/ACE2 ratio [80]. This evidence concerns the gene ACE and obesity due to melanocortin 4 receptor deficiency.