In addition to these suggested molecular bases of RTN4/Nogo in BC carcinogenesis, our predicted PPI network might indicate several other genes, proteins, and signaling pathways associated with BC that are less commonly mentioned in RTN4 studies, such as NUS1, S1PR2, NGF/NTRK1-2, BACE1, and APP. The gene discussed is RTN4; the disease is breast cancer.