Once produced by SphK1, S1P binds to S1PRs and EGFRs, initiating several oncogenic signaling pathways implicated in BC, such as the NF-kB, STAT3 PI3K/AKT, Ras/Erk, Rak1/PLC, EGFR (HER2), and ERK1/2 pathways [62]. The gene discussed is HSPG2; the disease is breast cancer.