It is recommended that the labs offering CF carrier screenings assess a minimum panel of disease-causing CFTR variants; thus, when one member of a couple screens positive as a CF carrier or has CF, a limited genetic screening panel may be offered to the second partner, consistent with professional guidelines [30]. However, CFTR sequencing can provide additional carrier detection and permit a more refined reproductive risk assessment [66]. Here, CFTR is linked to cystic fibrosis.