Nonetheless, they have a clinical manifestation of FH (non-FH) that may be linked to polymorphisms in several other genes, including Apolipoprotein E (APOE), signal transducing adaptor family member 1 (STAP1) and ATP-binding cassette subfamily G members 5 and 8 (ABCG5/8) [29]. Here, APOE is linked to familial hyperaldosteronism.