Bovine spongiform encephalopathy (BSE or “mad cow” disease) in cattle, Creutzfeldt–Jakob disease (CJD) and variant CJD in humans, scrapie in sheep, and chronic wasting disease (CWD) in deer, elk, mice, and reindeer are some of the diseases associated with PrP aggregation [11]. This evidence concerns the gene PRNP and scrapie.