All entadaoside saponins 24–28 were able to prevent RA progression and ameliorate hyperalgesia, paw swelling and joint destruction in CIA rats by reducing pro-inflammatory cytokine levels, upregulating ubiquitin-editing enzyme A20 expression, inhibiting p38 and ERK1/2 in the periphery and phosphorylation of p38 in the spinal cord [110]. This evidence concerns the gene TNFAIP3 and rheumatoid arthritis.