TNF and rheumatoid arthritis: Gedunin (16), a limonoid-type triterpenoid isolated from several genera of the Meliaceae family, such as the Indian neem tree (Azadirachta indica), antagonized ROS production and reduced pro-inflammatory cytokine levels and iNOS expression in LPS-stimulated macrophages (RAW264.7 cells), TNF-α-stimulated FLSs (MH7A cells) and IL-1β-stimulated primary RA FLSs [96].