TNF-α- stimulated MH7A cells and IL-1β-stimulated human RA FLSs from the joints of RA patients; cells treated with 17 (0, 1, 2.5, 5, 10, 25, 50 75, 100 or 150 μM) for 24, 48 or 72 h after incubation with 10 ng/mL TNF-α (MH7A cells) or 2.5 ng/mL IL-1β (RA FLSs). This evidence concerns the gene IL1B and rheumatoid arthritis.