Significant reduction of paw edema and arthritis scores. Improvement of the spleen and thymus indexesReduction of TNF-α, IL-1β, IL-6, IFN-γ levels in CIA ratsIncrease in superoxide dismutase activity; reduction of malondialdehyde and superoxide anions levels and NADPH oxidase activityPotential therapeutic effects on RA may be ascribed to downregulation of inflammatory cytokine levels and attenuation of oxidative stress. The gene discussed is IFNG; the disease is arthritic joint disease.