Reduction of joint swelling, arthritis index score, inflammatory cell infiltration and synovial hyperplasia in CFA-induced ratsDecrease in levels of IL-1β and IL-18 in the rat serum and supernatants of THP-1 cells exposed to 1Inhibition of ROS production, blocking of NF-κB signaling and hindering the activation of the NLRP3 inflammasome. The gene discussed is IL18; the disease is Arthritis.