TNF and rheumatoid arthritis: RA FLSs treated with DMSO or 3 (0, 2.5, 5, 10 μM) for 24 h. Stimulation with TNF-α (0 or 10 ng/mL)CIA male DBA/1 mice; injected i.d. on day 0 with emulsion of BTIIC (100 mg) in CFA (1:1, v/v) and on day 21 with emulsion of BTIIC (100 mg) in IFA (1:1, v/v). CIA mice injected i.p. with 3 (20 mg/kg/day) or DMSO, for 21 days