TNF and rheumatoid arthritis: TNF-α-stimulated human RA FLSs (MH7A cells) at 20 ng/mL and treated with 2 (0, 0.5, 1 or 2 μM) for 24 hAA male Wistar rats; intragastric administration of 2 (0.8 mg/kg/day), vehicle (0.3% CMC-Na) or MTX (0.6 mg/kg/day), for 28 days, starting the next day after CFA immunization