Inhibition of the migration of FLSs in vitro (IC50 3.29 ± 0.15 μM) and decreased expression levels of iNOS, COX-2, MMP-2 and p38. Suppressed nitroso-oxidative stress and reduced the levels of iNOS, COX-2, IL-6 and MMP-2, both in vitro and in vivoDecrease in synovial hyperplasia, prevention of cartilage destruction, pain attenuation and amelioration of arthritis progression in vivo by abrogating the STAT3/NF-κB/Notch-1 signaling pathway in synovial tissue of arthritic rats. Here, NOTCH1 is linked to arthritic joint disease.