Lowering of arthritis score, paw thickness and front paw swelling on day 12Suppression of the gene expression of inflammatory cytokines downstream of NF-κB signaling and inactivation of the TLR signaling pathwayDownregulation of the expression levels of the genes encoding TNF-α, IL-1β, IL-6 and IL-12, and upregulation of IκBα transcript and protein expressionDecrease in the production of LTB4 and alteration of the gene expression of glucocorticoids. Here, TNF is linked to arthritic joint disease.