Significant body weight increaseDecrease in paw volume and arthritic index score and in activities of liver marker serum enzymes (SGOT, SGPT, ALP)Reduction of serum levels of TNF-α, IL-6, IL-1β and IL-10. Decrease in MDA levels and enhancement in activities of antioxidant enzymes; outcomes were comparable to diclofenac sodium18 reduced the higher protein levels of COX-2, iNOS, NF-κB, p-IκBα and IKKα in CFA-induced RA rats. This evidence concerns the gene NOS2 and rheumatoid arthritis.