Further radiological and histopathological analysis corroborated these findings, since considerably less articular damage was observed and arthritis cartilage destruction and inflammatory cell infiltration were highly decreased, possibly due to inhibition of Th1 and Th17 differentiation, enhanced IL-4, IL-10, IL-13 expression and increased CD4+ Foxp3+ cells [82]. The gene discussed is FOXP3; the disease is Arthritis.