Inhibition of arthritis index, amelioration of joint pathology, diminished hind paw swelling, enhanced blood rheology and synovial cell apoptosis and re-establishment of cytokine negative regulation of ROCK/NF-κB signaling pathwaysDecreased secretion of IL-6, IL-1β and TNF-α, inhibition of proliferation of synovial tissue, reduction of monocytes and lymphocytesDecreased levels of RhoA, ROCK1, ROCK2, p-NF-κBp65 and p-IκBα levels. Mechanistically, 3 downregulated ROCK/NF-κB signaling pathways. The gene discussed is IL1B; the disease is arthritic joint disease.