AKT1 and rheumatoid arthritis: Astragaloside (20), a saponin found in Astragalus membranaceus, suppressed excessive FLS proliferation in the AA rat model of RA through the inhibition of the expression of the long non-coding RNA (lncRNA) LOC100912373 and increased release of miR-17-5p, which binds to 3-phosphoinositide-dependent protein kinase 1 (PDK1) and prevents activation of the PDK1/Akt pathway [101].