Downregulation of IL-1β, increase in TNF-α, IL-6, IL-8, MMP-1 and MMP-3 levels in human RA FLSs and in joint tissues of CIA mice, in a dose-dependent mannerInhibition of NF-κB activations and modulation of the TAK-1/IKK/IκB regulators in human RA FLSs and joint tissues of CIA mice, in a dose-dependent mannerNLRP3, TXNIP and ASC expressions were blocked and the maturation of caspase-1 was decreased, in vitro and in vivoReduction of clinical arthritis score and cartilage destruction in ankle joints of CIA micePotential therapeutic action of 12 by modulation of NF-κB/NLRP3 inflammasome pathways. The gene discussed is MMP3; the disease is rheumatoid arthritis.