AKT1 and rheumatoid arthritis: Inhibition of pro-inflammatory cytokines (TNF-α, IL-1β and IL-8) in human RA FLSs through downregulation of FAK, PI3K, Akt and NF-κB signaling pathwaysAmelioration of paw swelling, cartilage damage and bone erosion in CIA mice and decreased serum levels of TNF-α, IL-1β, IL-6 and IL-8