Decrease in arthritis scores, inflammation scores of the ankle joints, hind paw swelling and ankle joint bone erosion in CIA miceReduction of Th17 cells and increased Treg cells, reversing the abnormal Th17/Treg ratio in the spleens of CIA miceIn vitro inhibition of Th17 cell differentiation, IL-17A secretion and STAT3 phosphorylation and decrease in mRNA levels of IRF4 and RORγT in splenic CD4+ cells under Th17 polarization conditions. The gene discussed is IRF4; the disease is Arthritis.