34 reduced the swelling rates of RA mice, decreased the degree of cartilage destruction and vasodilation, diminished protein expression of TNF-α and IL-6 and raised the protein expression of IL-10 and TGF-β in the ankle jointEnhancement of oxidative phosphorylation and reinforcement of the TCA cycle and the respiration of ETC. CD4+CD25+Foxp3+ Treg cell percentage was increased; lipids played a crucial role in the proliferation and differentiation of these cells. Here, CD4 is linked to rheumatoid arthritis.