TNF and arthritic joint disease: Reduction of arthritis index, joint synovial inflammation, paw edema and bone loss in CIA miceDecrease in both rat serum levels and mRNA expression of inflammatory cytokines (IL-1β, IL-6, IFN-γ and TNF-α) and inhibition of protein expression levels of JAK1, JAK2, STAT3 and p-STAT3 in the rat synovial tissueMolecular docking and molecular dynamics simulations revealed that 21 binds to IFN-γ and IL-1β