TNF-α-stimulated human RA FLSs at 10 ng/mL for 24 h and treated with 8 (0, 5 or 10 μM) for additional 24 hZIA in female SKG/Jcl mice; oral administration of 8 (10 or 25 mg/kg) or vehicle (90% glyceryl trioctanoate and 10% DMSO) or MTX (10 mg/kg), i.p., daily, for 3 consecutive weeks, starting on the 21st day after single i.p. injection of zymosan A (2 mg/mice). Here, TNF is linked to rheumatoid arthritis.