Decrease in clinical arthritis symptoms, paw thickness, histological and radiological changes and serum IgG1 and IgG2a levelsReduction of Th1/Th17 phenotype CD4+ T lymphocyte expansion and inflammatory cytokine productionDecreased expression and production of inflammatory mediators, in the knee joint tissue and RA synovial fibroblasts, through the downregulation of IKKα/β, ΙκBα and NF-κB. Here, CHUK is linked to arthritic joint disease.