IGF1 and major depressive disorder: Kang et al. found that 8 weeks of aerobic and resistance training effectively improved depression behavior, neuronal damage, and synaptic plasticity reduction induced by chronic unpredictable mild stress (CUMS), but the mechanisms were different: aerobic exercise intervened in depression through PGC-1α/ERRα/FDNC5, while resistance training intervened through activation of IGF-1/IGF-1R/Akt/mTOR [126].