IL6 and neoplasm: Moreover, mKRAS favors TME infiltration by MDSCs and T-cell exclusion through the increased tumor expression of CXCL1 and GM-CSF, promotes the downregulation of CCL4 expression, impeding DC recruitment, and has a pro-inflammatory role by activating the Sonic Hedgehog signaling pathway and stimulating the expression of IL-6, COX2, MMP7, and pSTAT3 [17,83,84,85,86].