TP53 and pachyonychia congenita: As mentioned before, the coexistence of high-TMB and MSI-H/dMMR occurs in 60% of PC and also shares several features, including a high prevalence of mucinous/colloid and medullary histology and a characteristic genomic landscape, with less common KRAS and TP53 mutations and more frequent JAK mutations with respect to microsatellite stable PC [78].