Another in silico study that also used molecular docking showed that compounds from Hedyotis diffusa Willd (i.e., β-sitosterol, quercetin, stigmasterol, kaempferol, 2-methoxy-3-methyl-9,10-anthraquinone) may have a therapeutic effect on RA by modulating the phosphatidylinositol 3-kinase/protein kinase B signaling pathways and targeting TNF-α, IL6, IL-, and target transcription factor p65 [25]. The gene discussed is TNF; the disease is rheumatoid arthritis.