Recently, it has been shown that IL-17 derived from Th17 cells and IL-8 and tumor necrosis factor-α derived mainly from macrophages are involved in the pathogenesis of steroid-resistant asthma and that these cytokines induce “NETosis”, a specific cell death of neutrophils, also involved in asthmatic airway inflammation [40]. The gene discussed is CXCL8; the disease is inflammatory response.