Moreover, new insights have been recently made regarding the underlying mechanism of CT pathogenesis, where it was found that the prolonged strong signaling which was mediated by the leukemia inhibitory factor (LIF)/LIF receptor (LIFR) and triggered by a CT infection is a key pathway involved in the more harmful sequelae, namely, infertility, ectopic pregnancy, and cancer [45]. The gene discussed is LIFR; the disease is Infertility.