KEAP1 and disorder of glycogen metabolism: He et al. [44] reported that NRF2 activation alters glucose and lipid metabolism; hepatocyte-specific NRF2 activation in a mouse model, caused by accumulation of p62 or inhibition of KEAP1 binding, resulted in hepatomegaly associated with increased glycogenosis, steatosis, and G2/M cell cycle arrest, favoring hyperplasia without cell division.