ESR1 and Insulin resistance: Mir-222-3p belongs to the mir-222 cluster, is abundant in plasma during 24–28 weeks of gestation, and is a placental miRNA that acts on the proliferation of endometrial stromal cells [51,84], regulating the expression of estrogen receptor-α (ER-α) in estrogen-induced insulin resistance in GDM [55,62], and is strongly linked to glucose metabolism in pregnancy, profoundly impacting in the weight birth [51].