Clinico-pathologic factors related to the tumor, such as the tumor size and number, presence of microvascular invasion, poor histologic grade, and preoperative levels of α-fetoprotein (AFP) and prothrombin induced by vitamin K absence-II (PIVKA-II), have been reported to be associated with tumor recurrence after hepatic resection [6,7,8]. The gene discussed is AFP; the disease is neoplasm.