It is defined by the International Ascites Club as AKI in patients with cirrhosis, acute liver failure, or acute-on-chronic liver failure which does not show full or partial response after at least two days of diuretic withdrawal and volume expansion with albumin (1 g/kg of body weight per day to a maximum of 100 g/day) in the absence of shock, treatment with nephrotoxic drugs, and absence of parenchymal kidney disease [49]. The gene discussed is ALB; the disease is acute-on-chronic liver failure.