Developmental regression, autism, and epilepsy can also be seen in disorders of ion channels (i.e., Dravet syndrome), impairments of receptor expression (i.e., GRIN1), transcription factors (i.e., MEF2C), axonal guidance (i.e., NTNG1), and ubiquination (i.e., RHOBTB2) [48]. The gene discussed is MEF2C; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.