Developmental regression, autism, and epilepsy can also be seen in disorders of ion channels (i.e., Dravet syndrome), impairments of receptor expression (i.e., GRIN1), transcription factors (i.e., MEF2C), axonal guidance (i.e., NTNG1), and ubiquination (i.e., RHOBTB2) [48]. This evidence concerns the gene RHOBTB2 and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.