INS and diabetes mellitus: Given the ultimate goal of using the specific complexes in biological studies assessing their biochemical activity under pathophysiological conditions in humans (in the present case, diabetes mellitus, especially type 2, which is due to significant insulin resistance) [40], physicochemical characterization of the arisen species in the solid state (elemental analysis, FT-IR, TGA, and X-ray crystallography) was pursued into the solution state over time, with ESI-MS spectrometry defining the species arising upon dissolution of the requisite compounds to be employed in biological studies.