Genetic and epigenetic molecular patterns that promote prostate carcinogenesis are the loss of PTEN, amplification and overexpression of MYC, fusion between TMPRSS2 and ERG, inactivation of RB and P53, and dysregulation of Krüppel-like factor 5 (KLF5) [136]. Here, KLF5 is linked to urogenital neoplasm.