Mechanistically, circDLG1 interacted with miR-141-3p, resulting in the upregulation of the miR-141-3p target gene C-X-C motif chemokine 12 (CXCL12), which induced infiltration of myeloid-derived suppressor cells (MDSCs) to impair the function of CD8+ T cells and promoted GC progression [97]. Here, CXCL12 is linked to gonorrhea.