CXCL12 is a chemokine that binds to receptors CXCR4 and CXCR7 and regulates tumor metastasis through different mechanisms, such as facilitating proliferation, angiogenesis, and colonization, affecting endothelial adhesion, eruption from blood vessel and evasion from host immune response by activation of key pro-survival pathways, such as the previously mentioned JAK/STAT signaling and ERK/MAPK and PI3K/AKT/mTOR signaling pathways [131]. The gene discussed is CXCL12; the disease is neoplasm.