Upregulation of miR-141-3p suppresses EMT, migration and invasion of PC cells and reduces bone metastasis in vivo via inhibition of NF-κB signaling; MiR-141-3p decreases in bone metastatic PC tissues (compared to non-bone metastatic PC); low miR-141-3p correlates with higher PSA level, Gleason grade (differentiation) and bone metastasis status. This evidence concerns the gene NFKB1 and pachyonychia congenita.