LDLR and infection: Here, we demonstrate that lentiviral pseudovirions pseudotyped with SARS-CoV-2 spike protein can infect ARPE-19, a human retinal pigment epithelium cell line, in culture, and that this infection could be blocked by anti-LDLR, anti-Caveolin1, and anti-Dynamin antibodies, cholesterol-depletion agents, as well as by LDLR siRNAs.