STAT3 and tarsal-carpal coalition syndrome: It is noteworthy that, in all sertindole-treated TCC cell lines, the levels of tyrosine 705-phosphorylated STAT3 (p-STAT3) were lessened dose-dependently, along with a paralleled decrease in the expression levels of BCL-xL, an antiapoptotic protein and a well-established STAT3′s transcriptional target (Figure 3A, top panel).