GRIN1 and schizophrenia: In support of this, studies in rodents have shown that knockdown of the obligatory GluN1 subunit of the NMDAR can result in phenotypes relevant to schizophrenia, including hyperlocomotion (proposed to be indicative of a striatal hyperdopaminergic state which underlies positive symptoms such as psychosis), anhedonia, social deficits, impaired learning and abnormal neuronal oscillations [77,78,79,80,81,82].