DISC1 and schizophrenia: This study also found that GluN2D ablation from PV interneurons resulted in a downregulation of genes involved in GABAergic and dopaminergic synapse function such as GAD67 and TH, as well as schizophrenia susceptibility genes such as Disc1, ErbB4 and their downstream targets [196], thus suggesting a critical role for the GluN2D subunit in PV cells in modulating schizophrenia-relevant changes in neural circuitry, signalling and behaviours.