Increased levels of PS−-EVs carrying connexin-43 (CX43+/AV−-EVs) were observed in the cHF patients in comparison with the non-HF subjects (p < 0.001), while CX43+-PS+-EVs were found in comparable proportions in non-HF controls and cHF patients (p = 0.083). The gene discussed is GJA1; the disease is hydrops fetalis.