Leukocyte-derived EVs (LEVs) carrying pan-leukocyte CD45+ (LCA) antigen and CD29+ (β1 integrin), a marker of activated leucocytes, were found to be enriched in PS+-EVs, whereas monocyte CD14+ (LPS-receptor) epitope was found to be enriched in the PS−-EVs population both in the non-HF individuals and cHF patients (p ≤ 0.002, all) (Figure 3). The gene discussed is ITGB1; the disease is congestive heart failure.