The endothelium-originated PS−-eEV levels were higher in cHF patients compared to non-HF subjects, for both eEVs presenting markers of non-activated (CD309+/AV− (VEGFR2); p < 0.001) and activated (CD62E+/AV− (E-selectin); p = 0.007) endothelial cells. This evidence concerns the gene SELE and hydrops fetalis.