In the cHF group, the total number of cEVs was 1079 (426–4702)/μL, and of those, 16% were PS+-EVs and 84% were PS−-EVs, indicating a differential exposure of PS (annexin V [AV]+ and AV−) in cEV membranes in non-HF individuals and cHF patients (p < 0.001, both), as well as between both groups (p = 0.022 (for PS+-EVs) and p = 0.007 (for PS—EVs), respectively). This evidence concerns the gene ANXA5 and hydrops fetalis.