In contrast, endothelial-derived EVs (CD309+-eEVs; vascular endothelial growth factor receptor 2 (VEGFR2)) without PS membrane exposure (PS−) occurred with a frequency of 13% in the non-HF and 23% in the cHF (p = 0.012) subjects, while levels of CD309+/AV+-eEVs were almost null both in the non-HF and cHF groups. Here, KDR is linked to hydrops fetalis.