On the other hand, the lncRNA MGC contributes to the development of renal fibrosis in early diabetic nephropathy via the regulation of ER Degradation-Enhancing Alpha-Mannosidase-Like Protein 3 (EDEM3) expression [19], a molecule that is involved in the presentation of endogenous antigens [12]. Here, EDEM3 is linked to renal fibrosis.