These findings suggest that in low-income countries, having a functional P2X7 might be beneficial to protect against infections such as Plasmodium, Mycobacterium, and Chlamydia, while in high-income countries with an older population, an anti-inflammatory P2X7 phenotype is selected for, conferring protection against chronic inflammatory diseases such as AD [40]. This evidence concerns the gene P2RX7 and Alzheimer disease.