P2RX7 and Alzheimer disease: Upon stimulation of hippocampal brain slices with the agonist Bz-ATP, the release of both glutamate and/or GABA was observed [71], yet this effect was found to be associated with the presence of P2X7 specifically in astrocytes rather than neurons, indicating their potential involvement in the excitotoxic effects of glutamate and neuronal inhibition in AD [72,73] (Figure 1 and Table 2).