Increased levels of P2rx7 mRNA and P2X7 protein were first demonstrated in different mouse models of AD, specifically the transgenic mouse lines that develop amyloid plaques Tg2576 (Prnp-HuAPP*KM670/671NL) [14], APPSwe/PSEN1dE9 (Prnp-Mo/HuAPP*KM670/671NL, Prnp-HuPSEN1*ΔE9) [15], APPPS1 (Thy1-HuAPP*KM670/671NL, Thy1-HuPSEN1*L166P) [20], and J20 (PDGF-HuAPP*KM670/671NL and V717F) [21]. Here, P2RX7 is linked to Alzheimer disease.