Very interestingly, recent work by Scialò et al. highlighted the possibility of using RT-QuIC to identify the presence of TDP-43 on CSF, exploiting both the excellent level of technology achieved and the prion-like behaviour of the protein aggregates, providing considerable insight into the early detection of this finding in patients with ALS and FTD [200]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.