Mechanistically, BHLHE41/DEC2 binding sites in MLL-AF6 leukemia cells were enriched with H3K4me3 and H3K27ac transcriptionally active markers across the genome and activates genes related to the cell cycle, TGF-β signaling, FoxO signaling, HIF-1 signaling, and cancer [30]. This evidence concerns the gene AFDN and leukemia.