EPAS1 and neoplasm: In TNBC cells, BHLHE41/DEC2 can bind and inhibit HIF-1α and HIF-2α functions by promoting their proteasomal degradation that is independent of the von Hippel–Lindau tumor suppressor, which is an E3 ligase of HIF-1α and HIF-2α proteins, and suppress tumor invasion and metastasis in an in vivo model [18].