SDC2 and colorectal carcinoma: Several other peripheral biomarkers for CRC diagnosis, including methylation of SEPT9, SDC2 and VIM [120], evaluation of QKI gene methylation [121], and long noncoding RNA promoter region LINC00473 [122] in cell-free plasma DNA, have also shown high performance in early detection of affected patients, although their implementation in commercial tests has yet to be proposed.