SDC2 and colorectal carcinoma: It is interesting to note that serum SDC2 methylation was previously found to be highly sensitive and specific for the identification of CRC patients [119], and a recent meta-analysis including results of 12 articles confirmed the high potential diagnostic utility of methylated SDC2 detection in stool and plasma to be used as a CRC biomarker, reporting a sensitivity and a specificity of 0.81 and 0.95, respectively [87].