Patients with genetic defects in focal adhesion mediators or components of the TGF-β signaling cascade are predisposed to thoracic aortic aneurysms (TAAs) with manifestations of syndromic TAAs such as Marfan syndrome (MFS), Loeys–Dietz syndrome (LDS), or TAAs alone [47,48,49,50,51,52,53,54,55]. The gene discussed is TGFB1; the disease is Marfan syndrome.