Factors involved in tumor-mediated NET formation include tumor-derived inflammatory and chemoattractant cytokines (IL-8, IL-6, TNF-α, G-CSF and IL-1β) [189,190,196,197,198,199], tumor extracellular vesicles [200], tumor-activated platelets [201,202], tumor-derived HMGB1 [203,204,205,206], KRAS oncogene mutation [207] and hypoxia [208]. Here, HMGB1 is linked to neoplasm.