CXCR1 and metastatic melanoma: SX-682 (a CXCR1/2 antagonist) in combination with pembrolizumab entered Phase 1 trials in metastatic melanoma (NCT03161431), while a combination of avarixin (CXCR1/2 antagonist) and pembrolizumab is being trialed in advanced/metastatic solid tumors in a Phase 2 study (NCT03473925).