TP53 and Familial prostate cancer: In line with these findings, Sun et al. demonstrated that DHA upregulates the gene expressions of Caspase-9, Caspase-3, DFFA, TP53, BAX, CIDEA, TNF, TNFRSF1A, Caspase-1, and LTA, while downregulating XIAP, AIFM1, BIRC6, AKT1, and BID in human prostate cancer DU145 cells [96] (see Figure 4A).