This is in contrast to a recent report on the prognostic value of Pin1 in cancer, which examined data from 20 published studies involving 2474 patients and concluded that Pin1 overexpression was significantly associated with advanced clinical stage of cancer, lymph node metastases, and poor prognosis, though no correlation with poor differentiation was found [96]. Here, PIN1 is linked to metastatic malignant neoplasm in the lymph nodes.