On one hand, it has been shown to act as a tumor suppressor and a prognostic factor in cancers, while, on the other hand, it participates in tumor aggressiveness [30,31,32,33,34,35] Goh et al. showed that NSC49652, which is a small molecule that targets the p75NTR transmembrane domain, can induce apoptosis of melanoma cells acting through p75NTR, taking advantage of the fact that several cancers, such as neural crest-derived melanoma, express high levels of p75NTR [36]. This evidence concerns the gene NGFR and cancer.