CCL4 and neoplasm: To successfully infiltrate a tumor, the T cell has to upregulate several integrins, and the chemokine receptors CXCR3 (the receptor for the chemokines CXCL-9, CXCL-10 and CXCL-11) and CCR5 (the receptor for the chemokines CCL-3, CCL-4 and CCL-5) [175] and the cells of the tumor have to produce the corresponding chemokines and receptor ligands.