During immunogenic cell death (ICD), three damage-associated molecular patterns (DAMPs) are released: high mobility group box 1 (HMGB1), extracellular adenosine triphosphate (ATP) and cell surface-expressed calreticulin (CRT), which act as adjuvants to enhance dendritic cell (DC) uptake and cross-presentation of tumor antigens to T lymphocytes in draining lymph nodes (DLNs) [243]. This evidence concerns the gene CALR and neoplasm.