In a preclinical mouse model of CRC, Reis et al. [130] showed that in small tumors, cytotoxic Vγ7 and Vγ1-positive cells that produce IFN-γ are essential for tumor surveillance, whereas later, when the tumor grows, IL-17-producing Vγ6+ T cells promotes tumor growth. The gene discussed is IFNG; the disease is neoplasm.