Previous transcriptomics studies profiling the differentially expressed genes in peri-implantitis have pointed out that the significantly altered pathways were related to extracellular matrix molecules [26], matrix-degrading enzymes [27] and inflammatory pathways including the RANKL/OPG pathway and the cyclooxygenase2 pathway [28]. The gene discussed is TNFSF11; the disease is Peri-Implantitis.