Of the utmost interest, we further confirmed in the GBM CSC that neuraminidase administration drastically reduced the expression of the five selected genes (p < 0.001 for OLIG2, CHI3L1 and TIMP3; p < 0.01 for TNFAIP2 and p = 0.054 for TNFAIP6). This evidence concerns the gene CHI3L1 and glioblastoma.