Since these three cell lines exhibit a distinct transcriptomic profile, as previously reported for GBM6 and GBM9 [19], and epigenetic profile (present study), this result emphasizes that the strong decrease in OLIG2 gene expression both at the transcriptome level but also at the protein level after neuraminidase administration might affect all GBM subtypes. This evidence concerns the gene OLIG2 and glioblastoma.