The analysis of IgG autoantibody reactivity to Lens epithelium-derived growth factor splice variant of 75 kDa (LEDGF/p75) in patients with BPH showed that autoantibody reactivity to LEDGF/p75-overexpression cells in about 50% of patients with BPH was significantly increased [109]. Here, PSIP1 is linked to benign prostatic hyperplasia.