One study showed that myofibroblasts are associated spatially with BPH glandular components that overexpress IL-8 [116] and the regulation of myofibroblast differentiation and tenascin-C expression by IL-8 [117], indicating that myofibroblasts and IL-8 were involved in the development of BPH. Here, CXCL8 is linked to benign prostatic hyperplasia.