Comparing the LPS-treated to non-treated BBB model in analogous glycemic conditions, over the 36 h after LPS administration (time points 12 h, 24 h, and 36 h; Figure 5, Figure 6 and Figure 7), the SIRT1 concentration in the BC was similar in LPS-treated and non-treated groups for hypo- and normoglycemia and was much higher in LPS-treated BC for hyperglycemia at time point 12 h, but it was considerably lower for all glycemic backgrounds in LPS-treated groups at time points 24 h and 36 h. Here, SIRT1 is linked to Hyperglycemia.