Interferon-gamma (IFN-γ) is a pro-inflammatory cytokine involved in transcriptional regulation of immunologically relevant genes, and we reported that priming with IFN-γ enhanced the therapeutic effects of Wharton’s jelly-derived MSCs in a murine AD model and demonstrated the involvement of immune pathways in Wharton’s jelly-derived MSCs primed with IFN-γ by bioinformatics analyses [14]. This evidence concerns the gene IFNG and Alzheimer disease.