Consistently, dermal thickness was significantly lower in mice administered IFN-γ-iExo (low dose: 235.4 ± 27.7 μm, high dose: 224.9 ± 35.1 μm) than in the AD control group (400.3 ± 40.5 μm) (Figure 5D,G). Here, IFNG is linked to Alzheimer disease.