IFNG and Alzheimer disease: On the contrary, both SC and EP administration of IFN-γ-iExo resulted in significantly lower epidermal (20.9 ± 1.2 μm, 19.1 ± 0.8 μm, respectively) and dermal thickness (195.4 ± 17.6 μm, 166.5 ± 11.8 μm, respectively) compared to the AD control group (Figure 4D,E), as well as a significant reduction in the number of eosinophils, neutrophils, and lymphocytes (Figure 4D,F).