Our study also determined that the PLSCR4 (phospholipid scramblase 4) gene showed differential expression, with the highest expression occurring in AD dogs before therapy (0 vs. ctrl; 0 vs. 6 months), whereas its expression in the healthy control dogs and in the cAD patients after ASIT was similar (6 months vs. ctrl). This evidence concerns the gene PLSCR4 and Alzheimer disease.